![]() Hongwei Yu, MD, Bin Pan, PhD, and Quinn Hogan, MD, are developing novel modes of therapy for treating chronic pain, including stimulation of the dorsal root ganglion and manipulation of sensory neuron molecular function by genetic therapy with adeno-associated virus treatment. Neurobiologyĭisruption of neurological function is a focus of interest in anesthetic topics ranging from acutely disordered autonomic function during anesthesia to chronic mechanisms maintaining prolonged painful conditions. "Parent/Nurse-Controlled Analgesia Compared with Intravenous PRN Opioids for Postsurgical Pain Management in Children with Developmental Delay: A Randomized Controlled Trial." Pain Med 2018, 19:742-752. Representative publication: Czarnecki ML, Hainsworth KR, Simpson PM, Weisman SJ. Research psychologist Keri Hainsworth, PhD, together with clinic director Steven Weisman, MD, and other staff, examine behavioral health issues including the influence of co-exiting diseases such as obesity on the experience of pain, and the optimization of pain treatments in this understudied population. Clinical research is an important component of the center’s mission. Pettit Pain & Headache Center in Children’s Wisconsin. Our Department provides advanced pain care for children and adolescents at the Jane B. “A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits.” Anesthesiology 2017,127:502-14. Representative publication: Miller JR, Zuperku EJ, Stuth EAE, Banerjee A, Hopp FA, Stucke AG. Using animal models to better understand the mechanism of action underlying this phenomenon will allow improved definition of the age group at risk for opioid-induced respiratory depression and will aid the development of specific therapeutic strategies to counteract this serious side effect of opioid analgesics. Work currently underway by pediatric anesthesiologists Astrid Stucke, MD, and Eckehard Stuth, MD, together with Ed Zuperku, PhD, is expanding this knowledge by identifying the ventilatory suppression effects of opioids, which poses a particular risk in young infants. Our past work has defined the effect of various anesthetics and analgesics on ventilatory drive and gas exchange, providing fundamental observations that are key to providing safe anesthesia. ![]() Respiratory function during anesthesia and analgesia The material below describes five areas of currently funded research activities. Our research teams not only generate critical new knowledge to make our clinical activities more effective and safer, but also provide an educational environment for learners at all levels from students to residents and postdoctoral fellows. Our long-standing and diverse research program examines numerous aspects of anesthesia care, using both clinical and preclinical research approaches.
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